Heel wat muzikanten hebben sinds het eerste echte groepsbegin in 1967/1968 in Santana gespeeld. Hieronder staan deze onstage-muzikanten gegroepeerd op instrument. Voor sessie-muzikanten, gastmuzikanten is er ook plaats ingeruimd met vermelding van jaar, waar bekend.

Onstage met Santana...

Gitaristen
Carlos Santana, Tom Fraser, Neal Schon, Buddy Miles, Chris Solberg, Alex Ligertwood, David Sancious, Myron Dove, Tommy Anthony

Keyboardspelers
Gregg Rolie, Alberto Gianquinto, Robert Hoggins, Tom Coster, Richard Kermode, Leon Patillo, Chris Rhyne, Alan Pasqua, Richard Baker, David Sancious, Sterling Crew, Chester Thompson, Patrice Rushen, Freddie Ravel, Dave Matthews

Bassisten
Sergio "Gus" Rodriguez, Steve LaRosa, Dave Brown, Ron Johnson, Tom Rutley, Doug Rauch, Byron Miller, Pablo Tellez, David Margen, Keith Jones, Alphonso Johnson, Benny Rietveld, Myron Dove

Drummers
Danny Haro, Rod Harper, Bob "Doc" Livingston, Michael Shrieve, Greg Errico, NDUGU Leon Chancler, Gaylord Birch, Graham Lear, Chester Thompson, Tommy Bradford, Walfredo De Los Reyes, Billy Johnson, Ricky Wellman,  Horacio "El Negro" Hernandez, Rodney Holmes, Dennis Chambers, Jose Pepe Jimenez, Cindy Blackman-Santana

Percussionisten
Michael Carabello, Marcus Malone, Jose "Chepito" Areas, Rico Reyes, Coke Escovedo, Pete Escovedo, Victor Pantoja, James "Mingo" Lewis, Armando Peraza, Francisco Aguabella, Raul Rekow, Orestes Vilato, Paoli Mejias, Bobby Allende

Zangers
Gregg Rolie, Rico Reyes, Leon Thomas, Leon Patillo, Greg Walker, Luther Rabb, Joel Badie, Alex Ligertwood, Buddy Miles, Tony Lindsay, Vorriece Cooper, Curtis Salgado, Dave Matthews,  Andy Vargas, Ray Green

Blazers
Luis Gasca, Hadley Caliman, Joe Farrel, Jules Broussard, Russel Tubbs, Tower Of Powers blazers, Wayne Shorter, Bill Ortiz, Jeff Cresman, Ray Green

Sessie-studiomuzikanten met Santana...

Marty Olachea (wrongly credited as Mario Ochoa), Linda Tillery, Lenny White, Douglas Rodrigues, Joe Farrel, Alice Coltrane, Michael Carpenter, Paul Jackson, Jimmy Vaughn, Booker T. Jones, Willie Nelson,  Ronald Isley, Everlast,